CSPC2016 has ended
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Morley Hollenberg

My research interests over time have focused on the biosynthesis and actions of peptide hormones (oxytocin, vasopressin, insulin, epidermal growth factor) and on the molecular pharmacology and pathophysiology of receptor-mediated signaling by growth factors and G-protein coupled receptors (GPCRs). This focus seeks to understand rapid events occurring in tissues like smooth muscle, responsible for the regulation of blood vessel and intestinal motility. Recent work is studying the hormone-like signaling properties of proteinases that act in part via the ‘proteinase-activated receptor (PAR)’ family of GPCRs. The PARs regulate diverse pathophysiological processes ranging from vascular angiogenesis and contractility to arthritic and intestinal inflammation and pain. As one major focus, we are studying the activation of these receptors (PARs 1, 2 and 4) by thrombin, trypsin and other serine proteinases, like the tumour-derived tissue kallikrein family. We are particularly interested in the signalling pathways for the PARs that are in common with those for growth factor receptors, resulting in the activation of cellular tyrosine kinase pathways in the vasculature and other target tissues. A major direction related to signaling by proteinases seeks to identify, with the use of activity-based covalent proteinase labeling probes and proteomic analysis, those serine proteinases responsible for regulating cell and tissue function via the PARs in the settings of health and disease.